Research Topics
The laboratory of Genomics & Genome Engineering lab explores the regulatory mechanisms of mammalian development and disease progression using the state-of-the-art genome-wide technologies (e.g., RNA-seq, ChIP-seq etc.) and the advanced genome editing techniques (e.g., CRISPR/Cas9, base-editing, prime-editing etc.).
Current Research
01.
CRISPR-based Genome Editing for Disease Modeling
- Establishment of in vitro cell lines and in vivo mouse models
using CRISPR-Cas9, base editing, or prime editing
02.
NGS-based Analysis on Mammalian Genome Architecture
- Identification of mammalian gene regulatory networks through
RNA-seq and ChIP-seq analyses
03.
Human Gene/Cell Therapy for Personalized Medicine
- Development of novel gene and cell therapy platforms combined
with viral and exosome delivery systems
